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Dehydration can lead to hard, dry stools that are difficult to pass, increasing the likelihood of straining and rectal bleeding

PMID 17584130

This early evidence positions the pill as a promising oral GLP-1 medication at a time when more people want non-injection options for long-term weight management

Further research is needed to directly assess the comparative effectiveness and cost-effectiveness of combination therapy using each drug class individually, including the newer agents, semaglutide and tirzepatide

One of the biggest breakthroughs in the management of obesity and T2DM is the introduction of glucagon-like peptide-1 receptor agonists (GLP-1RA)