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Disruption of this rhythmicity due to sleep deprivation can impair the functioning of the HPG axis (15)

Irregular Bowel Movements: By reducing the localized inflammation and mast cell degranulation that drive rapid gut motility (diarrhea) or nerve-driven sluggishness (constipation), enzyme support helps normalize bowel function

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However, the researchers noted that statistically significant effects were weak and in part could be due to incidental change in the placebo group

How Tirzepatide Works Tirzepatide is a dual GIP and GLP-1 receptor agonist a single peptide that activates both incretin receptors at once