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Tirzepatide may cause slightly more headaches initially due to its dual receptor activation affecting both GLP-1 and GIP pathways in the brain simultaneously, though the data does not show a statistically significant difference between the two medications

Because it relies on the pituitary's own machinery, the GH release it produces follows the body's natural pulsing rhythm rather than overriding it

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Emerging evidences suggest prominent cardioprotective, hepatoprotective, reno-protective, anti-inflammatory and lipid-lowering capacity of alogliptin