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HpGroEL and HpTpx are covalently bound and inhibited by Metro and Metro-P3 after reductive activation As binding of Metro and derivatives to HpGroEL and HpTpx requires the in situ activation of the nitro group under microaerophilic or anaerobic conditions, direct inhibition and binding assays with purified enzymes in vitro were challenging (Supplementary Figs
Available at Published 03/31/2015
note that GLP-1s have been reported to quiet this process, hinting at a link between these drugs and reduced DMN-driven rumination [6]
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