In their research, the flavonolignans in milk thistle proved to be quite capable of absorbing ultraviolet rays, which is one of the two basic mechanisms for protecting the skin against solar radiation.27 Melasmas Melasmas are dark patches on the skin that may result from genetic factors, exposure to ultraviolet radiation, pregnancy, the use of cosmetics, and certain drugs or therapies (e.g., hormone therapy, anti-seizure medications)
Bartelson, K.M
However, it has previously been demonstrated that TMAO supplementation markedly downregulated the expression of critical enzymes in bile acid biosynthesis (CYP7A1 and CYP27A1) and hence reduced the size of the bile acid pool (Koeth et al., 2013)
When these side effects occur, they usually resolve on their own within a few days
BDNF/CREB signaling pathway contribution in depression pathogenesis: a survey on the non-pharmacological therapeutic opportunities for gut microbiota dysbiosis