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Oral semaglutide formulations produce different pharmacokinetic profiles, with more variable absorption and potentially different peaks and troughs in blood levels

Shah says he would caution people with type 1 who are not overweight to avoid taking a GLP-1 drug, since retrospective studies have found that this group tends to have more gastrointestinal side effects, which may lead them to stop using the drug

Tirzepatide also acts on GIP receptors, making it a dual agonist

Semaglutide delays gastric emptying by activating GLP-1 receptors in the stomach and pylorus, slowing the rate at which food and oral medications leave the stomach and enter the small intestine where absorption occurs

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