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at China Pharmaceutical University and Nanjing First Hospital: oral Dihexa restored spatial learning and memory in the APP/PS1 transgenic mouse model of Alzheimers disease via the PI3K/AKT signaling pathway, reduced neuroinflammation, and preserved hippocampal synaptophysin expression (Sun et al., Brain Sciences 2021)

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The trajectory is now visible: SELECT showed semaglutide reducing MACE in obesity without diabetes FLOW showed semaglutide's renal benefit in T2D + CKD STEP-HFpEF showed semaglutide improving HF symptoms in HFpEF + obesity SUMMIT showed tirzepatide reducing CV death and HF events in HFpEF + obesity The medications we have called "obesity drugs" are increasingly looking like what they really are: metabolic therapies that treat the diseases driven by obesity cardiovascular disease, kidney disease, heart failure, MASH

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