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Start gradually, particularly if Wegovy causes fatigue initially Sleep hygiene : Adequate, quality sleep (79 hours nightly) is essential for both mental health and metabolic regulation Stress management : Mindfulness, meditation, or relaxation techniques can complement antidepressant therapy Social connection : Maintaining relationships and engaging in meaningful activities supports mental wellbeing Nutritional considerations require particular attention when combining these medications: Adequate nutrition : Despite reduced appetite from Wegovy, ensure sufficient protein, vitamins, and minerals Hydration : Drink plenty of water, especially if experiencing gastrointestinal side effects Meal timing : Eating at consistent times may help manage nausea and maintain energy levels Dietitian referral : Professional nutritional guidance can optimise weight loss whilst preventing deficiencies Integrated care coordination : Your GP should ideally coordinate care between mental health services, NHS weight management services, and any other specialists involved in your treatment