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Mitochondrial depolarization enough to push the equilibrium led to a release of cytochrome c, leading to caspase-9 and caspase-3 activation, shown by the further cleavage of poly (ADP-ribose) polymerase (PARP), an accepted marker for the execution of apoptosis ( The extrinsic death receptor pathway is involved in caudatin-induced apoptosis due to the upregulation of death receptor 5 (DR5)

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2 Classification of natural products used in gastrointestinal (GI) disorders