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In vivo and in vitro studies have shown that Klotho enhances renal tubular cell autophagy and contributes to kidney protection via activation of AMPK and ERK and contributes to kidney protection pathways

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Considering the totality of evidence from clinical trials, post-marketing reports and observational studies, alongside the generally low incidence rate of NAION, Novo Nordisk believes that the benefit-risk profile of semaglutide remains favorable, the spokesperson said.

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