Langmuir 29, 37
Concentrations naturally decline with age (from about 200 ng/mL at age 20 to 80 ng/mL by age 60), which is part of why supplementation makes sense
Molecular Therapy, 25 (7), 1628-1640
Strain Route of Administration Dose Period of Administration Parameter Investigated Reference 0.1 g/mouse, everyday 5 days Gene expression in brain [75] 5 days Antioxidant properties, superoxide dismutase activity [11] HER-2/neu Subcutaneous injection 1 g/mouse, 5 times a week Until natural death Longevity of mice and incidence and count of new breast tumors [66,68,72] Tumor parameters, HER-2/neu mRNA expression [67,68] B-actin expression in mammary tumors [67] Stressor inuence [72] 1g/mouse, 5 consecutive days ev- ery month Life span, stressor inuence, longevity of mice, incidence, and count of new breast tumors [72] C3H/He Subcutaneous injection 0.1 g/mouse, 5 times a week 6.5 months Incidence, localization, and type of tumors [71] No data/ no strain Subcutaneous injection 5 g/kg Single dose Anomalies in sperm heads, presence of micronuclei in erythrocytes of peripheral blood, and hair color dependence [73] 2.4
The damage could be due to the high ROS generation
