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Substitutions in the amyloidogenic core region were used to disrupt the beta-sheet propensity that drives fibril nucleation, allowing the analog to remain soluble and monomeric at formulation-relevant concentrations

The methylcobalamin does have to be compounded but it is available in most areas

Benzyl alcohol disrupts microbial membrane integrity and interferes with microbial metabolic processes at concentrations sufficient to prevent colony growth but below cytotoxic thresholds for mammalian cells in most research applications

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