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Cross-age comparisons show that the genetic structures of pediatric and elderly IBD exhibit a bipolar differentiation VEO-IBD has the heaviest genetic burden: more than one-third of those with onset before age 6 carry single-gene defects, IL-10R mutations can be cured through hematopoietic stem cell transplantation [203,204,205], NOD2 biallelic mutations often lead to stricturing CD and high surgery rates [206],and rare defects such as lipopolysaccharide-responsive beige-like anchor protein (LRBA) and syntaxin-binding protein 2 (STXBP2) are also frequently observed [206, 207]

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These are moving lines on a LCD screen that changed their width, you might be familiar with it, and if the mouse moves its head in the right direction you score this, and its called the optomotor response

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