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As noted by Kraus et al., Nature Medicine and Ng et al., Journal of Endocrinology , targeting both systemic metabolism and localized fat cell activity may enhance fat-loss outcomes beyond either approach alone

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Conversely, cortisol deficiency (Addison's disease or secondary adrenal insufficiency) presents with fatigue, weight loss, hypotension, and potentially life-threatening adrenal crisis

Patient safety advice includes: Report persistent vomiting or signs of dehydration promptly to your healthcare provider Seek urgent medical care for severe abdominal pain, especially if radiating to the back Be aware of symptoms of hypoglycaemia if taking other diabetes medications Inform your doctor if you are planning pregnancy, as GLP-1 receptor agonists should be discontinued (at least 2 months before planned pregnancy for semaglutide) [1] [7] Attend regular follow-up appointments to monitor treatment response and side effects Suspected adverse reactions should be reported via the MHRA Yellow Card Scheme (yellowcard.mhra.gov.uk or via the Yellow Card app)