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The study looked at whether a combination of cardiovascular outcomes (heart attack, stroke, cardiac death, mini-stroke, urgent heart surgery for coronary disease) were more common in the allopurinol or the febuxostat group

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Freezing reconstituted peptides is generally discouraged because freeze-thaw cycles can cause aggregation and loss of activity

Ligand topologies were generated from SMILES strings using AceDRG 64 within the CCP4 suite 65 , with covalent bond geometry restraints manually adjusted in the phenix.refine parameter file

[#3] keep the patient deeply sedated for ~24 hours There is no high-quality evidence about how to do this