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Most WT proteins are marginally stable 22,23 , and, because most mutations are destabilizing, an evolving protein that accumulates mutations to access new properties will often lose stability 24,25,26

January 9, 2023

Quantitative analysis showed that the numbers of survived SGNs were reduced significantly in peroxynitrite-treated groups in a dose- and time-dependent manner compared with the control group (Figure 2B), that is, the higher concentration of peroxynitrite and the longer processing time induced more SGNs loss

Use formulations specifically designed for the eye area, typically at 2% or lower concentration

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