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A systematic review of randomised controlled trials indicated that berberine supplementation was associated with modest reductions in body weight and body mass index (BMI) in individuals with metabolic syndrome or type 2 diabetes

The combination of GLP-1RA and SGLT-2i was found to produce additive cardiovascular benefits compared to either treatment with one agent alone [33]

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GLP-1 therapy is highly effective for women over 40 because it targets appetite regulation, insulin resistance, and metabolic changes linked to aging and menopause

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