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GLP1-RA effects act in different metabolic pathways SGLT-2 drugs have also been effective in reducing the risk of diabetic kidney disease

Based on the results from above studies, the European and American Diabetes Associations have issued new recommendations strongly endorsing the use of SGLT2 inhibitors and GLP-1-R agonists in combination with metformin for patients with T2DM who have additional cardiovascular (CV) comorbidities or risk factors

placebo), thus demonstrating clinical efficacy [51]

[DOI] [PMC free article] [PubMed] [Google Scholar] 17.Jastreboff A

Integrated pharmacokinetic analyses revealed circulation times on the order of hours rather than minutes, providing a pharmacokinetic basis for sustained tissue signaling and glucose-lowering activity