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Effects are likely mediated via circumventricular organs (brain regions lacking a complete blood-brain barrier) and vagal afferent pathways, with limited direct penetration

Wu L, Liu G, Wang W, Liu R, Liao L, Cheng N, et al

Its published study focuses on the safety data - and not the efficacy data - which basically showed that those on the drug were lucky to lose one kilogram after 24 weeks

The current work comprised a small-scale exploratory study performed to assess the effects of pomegranate extract (PE) on blood pressure, stress hormone levels, insulin resistance, and the quality of life of healthy volunteers

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