to Avoid Those Side Effects, Try Reducing the Amount of Food You Eat by Half and Adjust as Needed From There
Always consult a doctor before taking or discontinuing any medication
Additionally, kidney disease can become a concern, especially if there is reduced urine output or swelling in the limbs
The largest psychiatric safety meta-analysis to date found that GLP-1 medications were not associated with increased risk of serious psychiatric adverse events overall ( Pierret et al., JAMA Psychiatry, 2025 ), and a post-hoc analysis of the major semaglutide weight management trials found no differences in depression, suicidal ideation, or suicidal behavior compared to placebo ( Wadden et al., JAMA Internal Medicine, 2024 )
The meta-analysis included 24 of these trials