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The mechanisms are complementary, making this combination theoretically rational

It enters circulation and activates the same gene expression cascades throughout the body affecting collagen synthesis in skin, wound healing in connective tissue, and potentially neuroprotection in the nervous system

HerzogAGFryeCAProgesterone Trial Study Group

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When the tissue is damaged, tissue proteases break down SPARC, releasing an array of GHK and GHK-containing copper-binding peptides, which stimulate cell proliferation and new vessels growth