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A 12-week cycle extends the optimization phase to 6 to 8 weeks before transitioning to maintenance

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NNMT inhibition reduces consumption of nicotinamide (and of S-adenosylmethionine) by blocking the enzyme that would otherwise methylate them

You can definitely opt for taking vitamin B12 supplements at night if that's what works best for you, although the natural energy-boosting abilities of vitamin B12 might be put to better use as you're starting the day