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This is in contrast to the postpubertal stage, where the reduced ER levels prevent the ER/IRS1 complex formation, and alter the signaling via the Raf/MAPK pathway [110]

Loguercio, C., D'Argenio, G., Delle Cave, M., Cosenza, V., Della Valle, N., Mazzacca, G., & Del Vecchio Blanco, C