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iPSC-derived liver organoids contain a resident macrophage and hepatic stellate cell population scRNAseq data identified a discrete population of Kupffer cells, which are the resident macrophage population of the liver and are derived in situ during the hematopoietic phase of liver development in vivo 59,60

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Furthermore, research links an increase in L carnitine dose to improved renal and liver function

In addition, cumulative evidence suggests that KOA as a metabolic disorder also requires energy metabolic pathways to meet the demands of tissue repair