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Further simulations showed that over a wide range of doxorubicin (050 M), the model can be used to suggest the specific concentration and exposure duration required to deplete cytosolic GSH by 70%, the threshold by which antioxidant defence is impaired, protein binding occurs, and cell death is possible
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J Chem Ecol 17, 451462
In some cases an MRI or ultrasound may be required to assess the severity of the condition as well as rule out other possible causes of pain3
Ruiz-Colon et al, 2014) Toxic Effects: May cause physiologic dependence & withdrawal symptoms after abrupt discontinuation (e.g
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