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The unique pharmacological profile of tirzepatide allows a greater engagement of the GIP receptor, mimicking the actions of native GIP, compared to the GLP-1 receptor, where it activates biased downstream signals favoring cAMP generation over beta-arrestin recruitment, resulting in reduced receptor internalization and degradation 2

322(4): C666

However, many of these articles primarily provide descriptive overviews of phytochemicals or focus predominantly on preclinical mechanistic findings without systematically integrating translational, clinical, pharmacokinetic, and safety dimensions within a single framework

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Jou MJ, Jou SB, Chen HM, Lin CH, Peng TI