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Patients with classic PCOS phenotype show alterations in the follicular fluid intermediate metabolites and the cumulus cells have an increase in oxidative stress, which causes the alteration of processes of follicular growth and oocyte development, causing the reduction in the pregnancy rate [61]

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Cysteamine-colon and cysteamine-duodenum lesions in rats

The SURMOUNT-1 trial showed average weight loss of 20.2 percent at 72 weeks on the highest dose, a figure that stunned the medical community when it was first published

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