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4a, NAC treatment markedly increased NADPH (+281 57 %, p = 0.035),while it diminished Kyn (55 16 %, p = 0.04), HCA (66 7 %, p = 0.0008), N-acetyl-glutamine (37 7 %, p = 0.015), succinic acid (34 6 %, p = 0.025), cytidine (50 9 %, p = 0.027), hypoxanthine (45 10 %, p = 0.032), cAMP (58 6 %, p = 0.033), methyl-malonic acid (33 7 %, p = 0.035), acetyl-coenzyme A (27 4 %, p = 0.044), flavone (46 11 %, p = 0.045), and CDP-choline (28 7 %, p = 0.048)

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Lu Z, Beck MH, Strand MR (2010) Egf1

Il targeting specifico del peptide sugli adipociti che esprimono NNMT consente uno spostamento metabolico localizzato senza una diffusa sovrastimolazione sistemica, presentando un modello unico per studi di modulazione selettiva della massa grassa

Persistent hypogonadism, testicular atrophy, and impaired spermatogenesis have been frequently reported, and complete recovery of reproductive function is not invariably achieved