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Carrol Strain for her assistance in proof reading and formatting the paper

The mechanism by which GLP-1 RAs potentially increase suicide or suicide attempts is unclear but may involve an overactivation of the hypothalamic-pituitary-adrenal (HPA) axis [7], rapid weight loss [8], and reduced expression of brain-derived neurotrophic factor which may link weight changes to heightened anxiety and suicidal risk [9]

Most experts now recommend viewing these medications as long-term treatments rather than temporary interventions

Lexarias GLP-1 Human Pilot Study #3 completes dosing as scheduled [Press release]