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Science 356(6340):853859 Ong ZY et al (2017) Paraventricular thalamic control of food intake and reward: role of glucagon-like peptide-1 receptor signaling

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Comprehensive toxicology evaluations reveal that the compound does not affect food intake, body temperature regulation, or basic physiological parameters at effective doses in animal models, indicating that its metabolic effects occur through specific pathway modulation rather than general physiological disruption

Neurotoxicity of domoic Acid in cerebellar granule neurons in a genetic model of glutathione deficiency

A signal that vanishes in two minutes is biologically elegant but pharmacologically useless you cannot inject something that disappears before it can do meaningful work