Additionally, Fe 3+ can be reduced to Fe 2+ via oxidizing GSH, accompanying the production of OH through a Fenton-like reaction
For patients with signs and symptoms of HT, close monitoring of labs (including antibodies that indicate autoimmune involvement) may help doctors detect this disease before serious consequences occur
GLP-1 receptor agonists, like Ozempic, Wegovy, Mounjaro, and Zepbound, initially developed for diabetes management, show promising potential in treating psoriasis and psoriatic arthritis (PsA)
However, GLRX has five cysteines that are potentially vulnerable to oxidative modification, which is associated with GLRX aggregation and loss of activity
doi: 10.1016/j.phrs.2022.106306 180 ShenHGengZNieXLiuT