Pilot clinical studies and case reports describe nausea in 65% of subjects at doses above 0,5 mg (resolution 2-4 h post-injection), flushing in 55%, transient increases in blood pressure and tachycardia in 40-60% of subjects, with peak acute effects occurring 90-120 minutes post-dose
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This interpretation is consistent with clinical observations that oral glutathione supplementation has limited bioavailability, favoring approaches that maintain precursor sufficiency instead of direct replacement [117,118,119]
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By using smaller dose increments, the transition is smoother and digestive side effects, including sulfur burps, tend to be less pronounced at each step