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Notably, several of the GLP-1 RAs examined in these studies (e.g., exenatide, lixisenatide) are gradually being retired from clinical use, while the therapeutic landscape is shifting toward newer GLP-1 RAs (e.g., semaglutide) and dual-or triple-agonist compounds (e.g., tirzepatide, retatrutide)

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Sodium, electrolyte, and energy losses also increase, especially during long, intense, or high-sweat sessions