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Refrigerate opened vials at 28C, mark the 28-day discard date, and treat temperature excursions as protocol failures

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This model entails that, upon androgen binding, AR is activated, loses interactions with chaperone proteins, translocates to the nucleus where it binds as a dimer to AREs and activates or represses transcription of its target genes with the assistance of a large interactome of regulatory proteins (Fig