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Notably, STZ-treated animals exhibit alterations in mitochondrial dynamics, including increased expression of fission proteins such as Drp1 and Fis1, accompanied by decreased levels of fusion-related proteins like Mfn2 and OPA1, particularly in the hippocampus and in the prefrontal cortex (Paidi et al., 2015
Thirst may arise from dehydration secondary to gastrointestinal side effects such as nausea, vomiting, or diarrhoea, or may signal hyperglycaemia or, rarely, diabetic ketoacidosis
Compounded drugs are not individually reviewed and approved by the FDA, and the agency has cautioned that some patients have had bad reactions to compounded GLP-1s because of incorrect dosing