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In conjunction with the fact that the high-GSH phenotype was evident within as little as 10 generations of culture with D-HIS (Fig

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In kidney diseases, gentamicin can induce nephrotoxicity, leading to impaired renal function, while Riceberry bran extract (RBBE) can initiate protective mechanisms in the kidneys via regulation of the PKC/NRF2 antioxidant defense pathway [49]

It is therefore unsurprising that the LD 50 values for compounds 1 and 2 determined ex vivo have a similar discordance to that seen for PZQ when considering in vivo PK/PD: much like PZQ these compounds are schistosomicidal in vivo at sub LD 50 concentrations