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Current role of mammalian sirtuins in DNA repair

(Oxf.) 71 , 466469 (2009)

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Furthermore, when p53 was inhibited, JNK phosphorylation was enhanced to induce more severe liver injury in the APAP model

The findings should be interpreted with caution as there were some methodological flaws, as a number of studies were judged to be either at high or unclear risk of bias for many domains, the review states