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Pre-existing risk factors : Individuals with established osteoporosis, previous fragility fractures, advanced age (particularly postmenopausal women), low baseline BMI, or those taking medications that affect bone metabolism (such as corticosteroids) may be more susceptible to bone density changes during weight loss

2 Many cell types express GLP-1Rs, including cells in the pancreas, digestive tract, heart and skeletal muscle, liver, central nervous system, and immune system, prompting multisystem interest among researchers studying GLP-1R agonists

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Karsdal MA, Byrjalsen I, Henriksen K, Riis BJ, Christiansen C

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