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doi: 10.3389/fphar.2025.1618079 Received 28 April 2025 Accepted 08 July 2025 Published 24 July 2025 Volume 16 - 2025 Edited by Karuna Rasineni, University of Nebraska Medical Center, United States Reviewed by Yang Yang, Chinese PLA General Hospital, China Asher Rajkumar Rajan, University of Nebraska Medical Center, United States Updates Copyright 2025 Xie, Yang, Tian and Chen

Serious but rare side effects: Pancreatitis (inflammation of the pancreas) Gallbladder problems Low blood sugar, especially if taken with insulin or sulfonylureas Allergic reactions Worsening diabetes-related retinopathy Always talk to your doctor if you have belly pain that wont go away, yellowing of the skin, or signs of low blood sugar (like shakiness or confusion)

Nature 434 , 652658 (2005)