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Given the predominance of capillaries in the brain's vasculature, their significant role in vascular resistance, and the extensive review of CBF control by smooth muscle cells (SMCs) elsewhere [54], this discussion focuses on capillary-based CBF regulation [26]

Weight Management Participants in the SURMOUNT trials experienced up to 22.5% total body weight reduction over 72 weeks, far exceeding results from existing GLP-1 therapies ( 2 )

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At a 20mg/mL concentration, maintenance doses stay in the comfortable range: 8mg requires 0.4mL (40 units) and 12mg requires 0.6mL (60 units)