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found that the hepatoprotective effect of Huangqi Decoction (HQD) on chronic cholestatic liver injury in mice induced by DDC (3,5-diethoxycarbonyl-1,4-dihydrocollidine) may be correlated with the upregulation of Nrf2 and induction of the Nrf2 signaling pathway (Figure 5) ( Liver Fibrosis The activation of hepatic stellate cells (HSC) is a critical reason for the production of extracellular matrix liver fibrosis