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In contrast, downregulation of hallmark E2F targets and MYC targets V1 with RETA hints at impaired cancer cell proliferation and tumor suppression (Fig

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These findings support the biological plausibility of a peripheral sensory contribution to GLP-1RA-associated changes in eating experience, but they do not establish that local taste-pathway modulation is sufficient to explain stable or consciously perceived alterations in flavour, food pleasure, or food-directed motivation in humans