3.1 Inhibition of NRF2 triggers ferroptosis Among the numerous mechanisms that regulate ferroptosis, NRF2 is a significant regulator of the antioxidant system, and its regulation of SLC7A11 has already been discussed
The acetyl-l-carnitine in this product, from the renowned Italian based Sigma-tau Pharmaceuticals company, is derived from a base of pharmaceutical grade l-carnitine manufactured by patented, FDA-approved process that fully complies with USP, FCC and EU monographs
Research shows it stimulates the production of collagen types I, II, and III, plus elastin, dermatan sulfate, and decorin all of the structural proteins that keep skin firm
Investigational Therapies Ganglioside-monosialic Acid ( GM1 ) The neuronal lipid ganglioside-monosialic acid (GM1) functions as a neuroprotective factor and has been investigated for prevention of CIPN based on promising findings in preclinical animal model studies (Wu 2021
& Kurashige, N