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This study has several limitations

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Metabolic interaction of folate and related B-vitamins Folate, vitamin B 12 , vitamin B 6 and riboflavin interact by functioning as cofactors within OCM, a network of interrelated cellular pathways essential for numerous biological processes, including the biosynthesis of DNA, amino acid interconversions and methylation reactions (Reference Bailey, Stover and McNulty5)

This review seeks to encapsulate the contemporary comprehension of ferroptosis's function in the aetiology of OA, emphasising its metabolic control and the ramifications for treatment strategies