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These infiltrating immune cells, in concert with fibroblast-like synoviocytes (FLS) and resident macrophages, promote chronic inflammation and stimulate the release of ECM-degrading enzymes and key factors such as receptor activator of NF-B ligand (RANKL), which enhance osteoclast differentiation and activity (192)

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It is possible that the inclusion of riboflavin could enhance the effects of iron-folic acid supplementation in treating maternal anemia, but the evidence is limited