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55 A sustained and amplified inflammatory response accelerates the release of abundant pro-inflammatory cytokines

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Dopaminergic projections from the SNc to the striatum (putamen and caudate) synapse on two major populations of dopamine receptor-mediated efferent neurons (referred to as the direct and indirect pathways), which, in turn, mediate motor activity via a complex neuronal circuit involving the extrapyramidal system (Fig