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Once reconstituted, refrigeration is recommended to preserve stability

Pham, M.-T

The injectable route of administration may also contribute to confusion, as vitamin B12 deficiency is traditionally treated with intramuscular injections, leading some to assume that injectable diabetes medications might contain vitamins

Some protocols incorporate topical application to specific areas of concern alongside injectable administration for localized plus systemic benefits

Still a third possible scenario exists, that being that the shot is so shallow that not only does one have the possibility of being near subcutaneous nerve fibril, but in addition one is so close to the skin that a small medicine bubble pops up