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PoeweWSeppiKTannerCMHallidayGMBrundinPVolkmannJet al

The role of HSPs in NDDs HSPs play a dual and indispensable role in NDDS: they either facilitate the correct folding and stabilization of misfolded proteins or target irreversibly damaged proteins for degradation via autophagy or UPS

Loss of the neurotransmitter dopamine, due to the degeneration of dopaminergic neurons in the midbrain underlies the pathophysiology of the motor dysfunction