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Preclinical studies indicate that these drugs shift macrophage polarization from a pro-inflammatory M1 to an anti-inflammatory M2 phenotype through HIF-1 downregulation and AMPK activation, enhancing tissue repair and reducing oxidative stress (95, 96)

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In 2021 and 2022, Pfizer $PFE and BioNTechs COVID-19 vaccine branded as Comirnaty was the top selling drug in the world with sales reaching a high of $37.8 billion in 2022

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