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Addressing side effects is not just about comfort
It became a popular thing to do when these weight-loss medications were in short supply, in 2025 and earlier, says Dr
That tells us appetite suppression is fundamentally a brain-mediated effect. The brain contains multiple, overlapping circuits that regulate feeding
Last reviewed: June 16, 2026 Last updated: June 16, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations
Of note, a similar pattern of HK2 expression to that we found in the single-cell RNA sequencing data set of CD patients (lowest in healthy controls and gradual increase from non-inflamed to inflamed tissue samples from IBD patients) has recently been reported in another cohort of IBD patients (100)
